basic FUNCTION
| selective regulator of dietary cholesterol absorption, also promoting biliary excretion of sterols |
|
sterol transporter may be playing a role in mediating apical cholesterol efflux in the gallbladder epithelium |
|
required to modulate biliary cholesterol secretion in response to the non-cholesterol steroids cholate and diosgenin |
|
bile acids may promote an active conformation of purified ABCG5/G8 either by global stabilization of the transporter or by binding to a specific site on ABCG5/G8  |
|
complex G5G8 mitigates the impact of a high fat diet on hepatic lipid accumulation and glucose intolerance  |
|
sterol transporters ABCA1, ABCG5, and ABCG8 may play a role in the pathogenesis of cholesterol-related gallbladder diseases (CAGD)  |