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FLASH GENE
Symbol MTBP contributors: shn - updated : 21-03-2012
HGNC name Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
HGNC id 7417
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  lowly Homo sapiens
Lymphoid/Immunespleen   lowly Homo sapiens
 thymus   highly Homo sapiens
Reproductivefemale systemovary  moderately Homo sapiens
 male systemtestis  highly Homo sapiens
 male systemprostate  lowly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to Mtbp, Mus musculus
ortholog to MTBP, Pan troglodytes
Homologene
FAMILY
CATEGORY regulatory , tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus,chromatin/chromosome,kinetochore
text localized at the kinetochores during prometaphase (
basic FUNCTION
  • putative growth regulator and tumor suppressor gene
  • promoting MDM2-mediated ubiquitination and degradation of TP53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner
  • differentially regulating the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and TP53) and in doing so significantly contributes to MDM2-dependent TP53 homeostasis in unstressed cells
  • a crucial role in proper mitotic progression and faithful chromosome segregation (
  • implicated in cancer progression
  • CELLULAR PROCESS cell cycle, checkpoint
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text tumor cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MDM2 (
  • suppresses cell migration, at least partially, by inhibiting ACTN4 function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • a potential biomarker for cancer progression
  • Therapy target
    ANIMAL & CELL MODELS
  • MTBP downmodulation leads to an abbreviated metaphase and insufficient mitotic arrest, abnormal chromosome segregation, aneuploidy, decreased cell proliferation, senescence, and cell death (