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FLASH GENE
Symbol ARIH1 contributors: mct - updated : 20-10-2013
HGNC name ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)
HGNC id 689
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Respiratorylung   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • N-terminal canonical RING1 has been shown to be the principal E2-binding region, although RING2 is also required for ligase activity
  • a highly acidic domain
  • a poly (gly) tract in the N terminus
  • two RING fingers and an IBR domains between RING fingers in the central region, with a RING2 from the RING-IBR-RING motif having a completely distinct topology from classical RINGs
  • HOMOLOGY
    interspecies ortholog to ariadne Drosophila
    homolog to murine Arih1
    Homologene
    FAMILY Ariadne subfamily ligases
    CATEGORY enzyme , unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing a role of an E3 ubiquitin-protein ligase
  • ARIH1 and PARK2 functioning via a HECT-like mechanism whereby RING1 harbours the E2-binding site and RING2 harbours the active-site cysteine
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • UBE2G2 (E2-UbcH7) through the RING1 finger domain
  • E2-UBCH8
  • interacts and co-localizes with UBE2L3 in mammalian cells, particularly in the perinuclear region
  • ARIH1, ARIH2 bind to and are activated by distinct neddylated Cullin-RING ligase complexes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS