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FLASH GENE
Symbol DMGDH contributors: mct - updated : 07-04-2020
HGNC name dimethylglycine dehydrogenase
HGNC id 24475
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 43AA leader peptide, N terminus
  • FAD dependent oxidoreductase
  • folate-binding domain
  • a C-terminal barrel domain
  • mono polymer monomer
    HOMOLOGY
    interspecies ortholog to rattus Dmgdh (86 pc)
    intraspecies homolog to SARDH
    Homologene
    FAMILY
  • Thi4 family
  • gcvT (Glycine cleavage T protein, aminomethyl transferase) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • catalyzing the oxidative demethylation of dimethylglycine to form sarcosine
  • playing a role in choline catabolism in the liver
  • mitochondrial enzyme that catalyzes the oxidative demethylation of dimethylglycine to sarcosine
  • plays a prominent role in choline and 1-carbon metabolism
  • mitochondrial enzyme which plays an important role in the utilization of methyl groups derived from choline
  • is a flavin adenine dinucleotide (FAD)- and tetrahydrofolate (THF)-dependent, mitochondrial matrix enzyme taking part in choline degradation, one-carbon metabolism and electron transfer to the respiratory chain
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    requires flavin adenine dinucleotide (FAD)
    protein
  • its expression suppresses metastasis through the AKT1 signaling pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DMGDHD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma
    constitutional       loss of function
    in diabetes development
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate gene for non-syndromic cleft lip with or without cleft palate (NSCL/P
    Marker
  • is a potential valuable biomarker for both diagnosis and prognosis for HCC (hepatocellular carcinoma)
  • Therapy target
    ANIMAL & CELL MODELS