protein
| interacting with SMAD2, SMAD3 through the nucleoplsmic C-terminal domain (negative regulator of SMAD2 and SMAD3) |
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interacts with nuclear lamins and emerin, thus playing a role in nuclear organization |
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binds simultaneously to R-Smads and their targeted DNA sequences |
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SMAD2-MAN1 interaction that regulates transforming growth factor-beta signaling at the inner nuclear membrane |
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LEMD3 is an integral protein of the inner nuclear membrane, inhibiting TGFB1 signaling by binding to SMAD2 and SMAD3 |
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nuclear envelope-localized mechanism of inactivating TGFB1 signaling in which LEMD3 competes with transcription factors for binding to SMAD2 and SMAD3 and facilitates their dephosphorylation by PPM1A |
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transcription of the core clock component ARNTL is positively modulated by the inner nuclear membrane protein LEMD3, which directly binds the ARNTL promoter and enhances its transcription |
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antagonizes TGFB1-SMAD2/3 signaling in a stiffness-dependent manner in both the nucleus and cytosol |
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integral protein of the inner nuclear membrane, and is a SMAD cofactor that terminates TGFB1 superfamily signals |
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A-type lamins and SUN2 play antagonistic roles in the modulation of profibrotic signaling through opposite effects on LEMD3 levels at the nuclear lamina |