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FLASH GENE
Symbol RBMS3 contributors: mct - updated : 23-01-2013
HGNC name RNA binding motif, single stranded interacting protein
HGNC id 13427
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 8234 - 434 - 2003 13679028
13 - 1740 - 420 - 2003 13679028
14 - 8186 - 421 - 2003 13679028
14 - 8180 - 419 - 2003 13679028
14 - 1779 - 433 - 2003 13679028
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver, cochlea
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two RNA binding motifs
HOMOLOGY
Homologene
FAMILY
CATEGORY RNA associated , transcription factor , tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • key regulator of profibrotic potential of HSCs (Hepatic stellate cells), representing a novel mechanism by which activated HSCs contribute to liver fibrosis
  • tumor suppression function in esophageal squamous cell carcinoma (ESCC), acting through MYC downregulation, with genetic loss of this gene in ESCC contributing to poor outcomes in this deadly disease
  • had a pro-apoptotic role in a mitochondrial-dependent manner via activation of caspase-9 and PARP1
  • function for RBMS3 as an important tumor suppressor gene in nasopharyngeal carcinoma
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • by binding PRRX1 mRNA in a sequence-specific manner, controls PRRX1 expression and indirectly collagen synthesis
  • inhibited microvessel formation, which may be mediated by down-regulation of MMP2 and CTNNB1 and inactivation of its downstream targets, including CCND1, MYC, MMP7, and MMP9
  • interaction between RBMS3 and ZNF516 influences bone mineral density
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in nasopharyngeal carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS