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FLASH GENE
Symbol SCHIP1 contributors: mct/npt - updated : 12-09-2022
HGNC name schwannomin interacting protein 1
HGNC id 15678
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2106 53.3 487 - Kwasnicka-Crawford (2006)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver   moderately
Endocrinepancreas   moderately
Nervousbrain   highly
Reproductivemale systemprostate  moderately
Respiratorylung   moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • coiled-coil domain
  • HOMOLOGY
    interspecies ortholog to C.elegans UNC76
    homolog to murine Schip1
    intraspecies homolog to FEZ
    Homologene
    FAMILY
  • FEZ family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • SCHIP1 is a cytoplasmic partner of cortical cytoskeleton ankyrins
  • early role for SCHIP1 during axon development and establishment of the anterior commissure (AC)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with schwannomin is regulated by conformational changes in schwannomin, possibly induced by posttranslational modifications, alternative splicing, or mutations
  • fused with IQCJ
  • IQCJ-SCHIP1 is likely to play a role in mature Axon initial segments (AISs) and nodes of Ranvier (NRs) rather than during their formation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS