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FLASH GENE
Symbol TAF1C contributors: mct/npt - updated : 17-06-2020
HGNC name TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
HGNC id 11534
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 splicing 3925 - 869 - 2015 25551296
15 splicing 3741 - 775 - 2015 25551296
12 - 3518 - 537 - 2015 25551296
14 - 3814 - 460 - 2015 25551296
15 - 3847 - 843 - 2015 25551296
11 - 3342 - 537 - 2015 25551296
12 - 3659 - 392 - 2015 25551296
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Nervousbrain   highly
 spinal cord   highly
Reproductivemale systemprostate  highly
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Taf1c
Homologene
FAMILY
CATEGORY DNA associated , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleoplasm
intracellular,nucleus,nucleolus
basic FUNCTION
  • playing a role in the initiation of transcription by RNA polymerase 1
  • initiation of transcription for ribosomal RNA (rRNA) by RNA polymerase I requires TBP and TBP-associated factors (TAF1A, TAF1B and TAF1C)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of SL1 (complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I), general transcription factor associated with POLR1, synthesis of 45S RNA precursors
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TP53 (Tp53 binds to SL1, and this interaction is mostly mediated by direct contacts with TATA-binding protein and TAF1C)
  • TBP loading by AFF1 through TAF1A, TAF1B, TAF1C is the major rate-limiting step in MLL fusion-dependent transcription
  • SPIN1 is required for the association or assembly of selective factor 1 (TAF1C) complex, probably facilitating the initiation of rDNA transcription
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    somatic frameshift mutations in in gastric and colorectal cancers
    constitutional     --over  
    in T2DM
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS