basic FUNCTION
| may be involved in gene expression or genome integrity |
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required for methylation of most imprinted loci in germ cells |
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required for the de novo methylation of imprinting control regions in female germ cells and for the de novo methylation of dispersed repeated sequences in male germ cells |
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stimulates de novo methylation by DNMT3A (Chedin 2002) |
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is thought to be required for the establishment of maternal genomic imprints |
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also mediates transcriptional repression through interaction with histone deacetylase 1 |