Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MLYCD contributors: mct - updated : 03-06-2020
HGNC name malonyl-CoA decarboxylase
HGNC id 7150
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2211 - 493 - 2016 26948533
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumcardiac  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region having no effect on the catalytic activity of the enzyme but playing a role in the folding process and conformation stability
  • C terminal peroxisomal targeting signal (PTS1) of serine, leucine
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text
  • STARD4 and cytosolic MLYCD act similarly by increasing the rate of transfer of sterol to the endocytic recycling compartment and to the ER
  • basic FUNCTION
  • cytoplasmic regulation of malonyl-CoA and their of mitochondrial fatty acid uptake and oxidation
  • peroxisome degrading intraperoxisome malonyl-CoA generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acid
  • potentially participating in the regulation of cytosolic malonyl-CoA levels and of hepatic fatty acid oxidation
  • key enzyme responsible for malonyl-CoA turnover and functions in the control of the balance between lipid and glucose metabolism
  • regulates fatty acid biosynthesis and converts malonyl-CoA to acetyl-CoA
  • can control the level of malonyl-CoA in cell through the decarboxylation of malonyl-CoA to acetyl-CoA, and plays an essential role in regulating fatty acid metabolism, thus it is a potential target for drug discovery
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MLYCD is a SIRT4 target
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MLYCD
    related resource MLYCD Allelic Variant Database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    with the decreased expression of ACACA and PRKAB1 are important regulators of the maturation of fatty acid oxidation in the newborn heart
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascular  
    potential therapeutic targets for the treatment of hypoxic pulmonary vasoconstriction and pulmonary hypertension
    ANIMAL & CELL MODELS
  • mice lacking the gene Mcyld do not show pulmonary vasoconstriction during exposure to acute hypoxia and do not develop pulmonary arterial hypertension during chronic hypoxia but have an otherwise normal phenotype