SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,matrix
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| intracellular,cytoplasm,organelle,peroxisome
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic
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text
| STARD4 and cytosolic MLYCD act similarly by increasing the rate of transfer of sterol to the endocytic recycling compartment and to the ER |
basic FUNCTION
| cytoplasmic regulation of malonyl-CoA and their of mitochondrial fatty acid uptake and oxidation |
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peroxisome degrading intraperoxisome malonyl-CoA generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acid |
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potentially participating in the regulation of cytosolic malonyl-CoA levels and of hepatic fatty acid oxidation |
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key enzyme responsible for malonyl-CoA turnover and functions in the control of the balance between lipid and glucose metabolism |
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regulates fatty acid biosynthesis and converts malonyl-CoA to acetyl-CoA |
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can control the level of malonyl-CoA in cell through the decarboxylation of malonyl-CoA to acetyl-CoA, and plays an essential role in regulating fatty acid metabolism, thus it is a potential target for drug discovery |