Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CCT2 contributors: mct/npt - updated : 26-03-2008
HGNC name chaperonin containing TCP1, subunit 2 (beta)
HGNC id 1615
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 1962 - 535 - Guo (2005)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Endocrineneuroendocrinepituitary  highly
Reproductivemale systemtestis  highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer
HOMOLOGY
Homologene
FAMILY
  • TCP-1 chaperonin family
  • TF55/TCP-1 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • assembled into a TCP1 ring and mediating ATP-dependent monomeric protein folding
  • decreases concomitantly with the reduction of chaperone activity during cell cycle arrest at M phase
  • required for maturation of sphingosine kinase 1 (Zebol 2009)
  • CCT complex is responsible for the folding of a number of proteins including actin and tubulin (Kabir 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a heterooligomeric complex (970kDa)
  • eight subunits that assists in the folding of actin, tubulin and other cytosolic proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS