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FLASH GENE
Symbol MYBBP1A contributors: mct - updated : 24-01-2015
HGNC name MYB binding protein (P160) 1a
HGNC id 7546
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
27 - 4122 149.2 1332 - 1999 10644447
  • isoform 1
  • 26 - 4585 148.7 1328 - 1999 10644447
  • isoform 2
  • a central acidic region
  • C-terminal basic amino acid repeats
  • a number of potential leucine charged domain motifs
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Endocrinepancreas    
    Lymphoid/Immunespleen   highly
    Nervousbrain    
    Reproductivefemale systemuteruscervix moderately
     male systemprostate   
    Respiratoryrespiratory tractlarynx  moderately
    Skin/Tegumentskin   moderately
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion highly in lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Mybbp1a (69.9 pc)
    homolog to murine Mybbp1a (71.3 pc)
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • predominantly nucleolar
  • shuttling between the nucleus and cytoplasm
  • nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1
  • when rRNA transcription was suppressed by nucleolar stress, MYBBP1A translocated to the nucleoplasm and facilitated TP53-EP300 interaction to enhance TP53 acetylation
  • nucleolar stress induces translocation of the nucleolar protein MYBBP1A from the nucleolus to the nucleoplasm and enhances TP53 activity
  • basic FUNCTION
  • may activate or repress transcription via interactions with sequence specific DNA-binding proteins
  • repressing JUN, MYB and PPARGC1A
  • stimulating transcription by AHR
  • may function to regulate cell type specific genes
  • may connect the ribosome biogenesis and the Myb-dependent transcription, which controls cell cycle progression and proliferation
  • novel substrate of AURKB and may be involved in mitosis (Perrera 2010)
  • regulates levels and processing of pre-ribosomal RNA (
  • co-repressor role of MYBBP1A in rRNA expression
  • is an essential gene with novel roles at the pre-mitotic level and potential tumor suppressor activity
  • plays catalytic roles in TP53 acetylation and activation
  • nucleolar stress induces translocation of the nucleolar protein MYBBP1A from the nucleolus to the nucleoplasm and enhances TP53 activity
  • likely plays a pivotal role in the cellular stress response
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding to JUN and MYB via the leucine zipper regions present in these proteins
  • binding to PPARGC1A
  • binding to AHR
  • binding to KPNA2
  • is a novel substrate of VHL
  • associated with both the RNA polymerase I complex and the ribosome biogenesis machinery
  • specifically interacts with nonacetylated TP53 and induces TP53 acetylation
  • MYBBP1A binds to SIRT7 and is a novel negative regulator of SIRT7
  • functions to enhance TP53 tetramerization that is necessary for TP53 activation
  • ANKH /MYBBP1A and SPHK1 interactions stimulate catabolic events in IL1B-mediated cartilage degradation
  • interaction of MYBBP1A with CDK2 and TPP2, to form a protein-protein interaction network
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS