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FLASH GENE
Symbol DDX17 contributors: mct - updated : 01-02-2018
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
HGNC id 2740
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 4805 80.3 729 - 2002 12138182
  • having a different 5' end compared to transcript variant 2
  • encoding two isoforms (p82 and p72) through the use of alternate translation initiation codons. Isoforms p82 and p72 result from the use of a non-AUG (CUG), and a downstream in-frame AUG start codon, respectively
  • - - 1880 23 183 - 2002 12138182
  • lacking most of the 5' exons found in transcript variant 1
  • initiating translation from a downstream in-frame start codon and encodes an isoform (2) that is considerably shorter than isoforms p82 and p72 encoded by transcript variant 1
  • 13 - 4811 - 731 - 2002 12138182
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemuterus  highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four N-terminal RGG box repeats
  • a central conserved DEAD box domain
  • a run of 7 glycines
  • a serine/glycine-rich C-terminal domain ending in 9 consecutive prolines
  • HOMOLOGY
    interspecies ortholog to rattus Ddx17 predicted
    ortholog to murine Ddx17
    Homologene
    FAMILY
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 family
  • DEAD box helicase family
  • DDX5/DDX17 subfamily
  • CATEGORY enzyme , regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,chromatin/chromosome,nucleosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly
  • acting as an RNA helicase
  • may be an alternative splicing regulatory factor
  • is required for optimal function of the zinc-finger antiviral protein.
  • DDX5 and DDX17 have been shown to act as transcriptional
  • co-activators for a diverse range of transcription factors, including oestrogen receptor-alpha (ESR1)
  • crucial role for DDX17 in ESR1 co-activation and oestrogen-dependent cell growth and likely distinct but important roles for both DDX5 and DDX17 in regulating ESR1 activity in breast cancer
  • critical role for DDX5 and DDX17 in tumor cell migration through the fine regulation of NFAT5 pathway
  • DDX5 and DDX17 are members of a large family of highly conserved proteins that are involved in gene-expression regulation
  • RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation
  • has dual roles in the recognition of stem loops: in the nucleus for endogenous microRNA (miRNA) biogenesis and in the cytoplasm for surveillance against structured non-self-elements
  • DDX17 is a SOX2-binding protein in ER-positive breast cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule nucleotide,
  • ATP
  • protein
  • DDX5 and DDX17 have a dual role in the control of the pro-migratory NFAT5 transcription factor
  • DDX5 and DDX17 act are transcriptional coactivators of NFAT5 and are required for activating NFAT5 target genes involved in tumor cell migration
  • binding between DDX17 and SOX2, although this interaction was largely restricted to reporter responsive (RR) cells
  • DDX17 and KHSRP influence AGO2 stability by regulating miRNA levels in the cell and that loss of DDX17/KHSRP results in a decrease of unloaded AGO2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    DDX17 inhibition may be a promising strategy to overcome acquired resistance of gefitinib in NSCLC patients
    ANIMAL & CELL MODELS