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FLASH GENE
Symbol TNRC6A contributors: mct - updated : 21-11-2018
HGNC name trinucleotide repeat containing 6A
HGNC id 11969
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 - 8495 210.3 1962 - 2017 28837617
  • GW220 or TNGW1
  • a unique N-terminal extension, containing an expanded polyglutamine (polyQ) repeat motif
  • could mediate repression without activating the rapid degradation of the associated mRNA
  • 24 - 8348 - 1913 - 2017 28837617
    GW182
    24 - 8526 195 1922 - 2017 28837617
  • contains an N-terminal extension but lacks the polyQ domain
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus   highly
    Digestivetooth    
    Reproductivemale systemtestis   
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveodontoblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RRM (RNA recognition motif) domain
  • a nuclear export signal (NES) and a nuclear localization signal (NLS)
  • C-terminal silencing domain of the GW/TNRC6 proteins interacts with PABP, PAN2/PAN3, and CNOT1/CCR4/CAF1
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Tnrc6a/Tnrc6
    intraspecies paralog to TNRC6B, TNRC6C
    Homologene
    FAMILY GW family protein
    CATEGORY transcription factor , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,nucleoplasm
    text
  • localize to the mammalian P bodies
  • its subcellular localization is regulated by its own nuclear localization signal and nuclear export signal
  • TNRC6A shuttles between the cytoplasm and nucleus
  • basic FUNCTION
  • may be having a role in regulating neurodevelopment or neuroplasticity
  • may be involved in structure/maintenance and/or stability of GW body (GWB) structures
  • might contribute to diversity in the formation and function of GW and/or P bodies
  • is likely an essential functional component in the RNA-induced silencing complex for miRNA-mediated gene silencing
  • could mediate repression without activating the rapid degradation of the associated mRNA
  • is capable of nucleating the de novo formation of GW/P bodies and is essential for their maintenance in mammalian cells
  • different TNRC6 proteins (TNRC6A, TNRC6B, TNRC6C) have likely distinct functions in different types of RNA granules
  • possibility that TNRC6A plays an important role in navigating AGO protein into the nucleus to lead miRNA-mediated gene silencing
  • is an essential protein for microRNA-mediated gene silencing
  • regulates splicing in the nucleus
  • TNRC6A/TNRC6B/TNRC6C are central organizing factors critical to RNA-mediated transcriptional activation
  • central scaffold that link microRNA-associated Argonaute proteins to the cytoplasmic decay machinery for targeted mRNA degradation processes
  • TNRC6A, TNRC6B, TNRC6C are required for transcriptional activation and for the activity of miRNAs but are dispensable for the regulation of splicing, transcriptional silencing, and the action of siRNAs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
  • binding
  • TNRC6A, TNRC6B, and TNRC6C silence the expression of bound mRNAs
  • small molecule
    protein
  • acted as a repressor in AGO2-mediated translational silencing
  • TNRC6A, TNRC6B, and TNRC6C are recruited to miRNA targets through an interaction between their N-terminal domain and an Argonaute protein
  • TRIM65 interacts and colocalizes with trinucleotide repeat containing six (TNRC6A, TNRC6B, TNRC6C) proteins in processing body-like structures
  • TNRC6A subcellular localization is substantially controlled by the interaction with Ago proteins, and this subcellular localization affects the RNA silencing activity
  • interactions observed between TNRC6A and KPNA2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BAFME6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS