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FLASH GENE
Symbol LILRB5 contributors: npt/ - updated : 07-12-2005
HGNC name leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5
HGNC id 6609
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2282 - 591 - -
12 - 1982 - 491 - -
13 - 2279 - 590 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Digestiveliver    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebonesubchondral  
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunenatural killer
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text spleen
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four extracellular Ig-like motifs
  • a single transmembrane domain
  • a cytoplasmic tail with two immunoreceptor tyrosine-based inhibitory-like motifs (ITIM), tyrosine based inhibitory motifs (ITIM), cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, that down-regulate signaling by nonreceptor tyrosine kinase cascades (Tedia 2008)
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • leukocyte immunoglobulin-like receptor family
  • related to the Fc alpha receptor and natural killed inhibitory receptor superfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text expressed in mast cell granules (Tedia 2008)
    basic FUNCTION
  • playing a role in regulation of immune responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS