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FLASH GENE
Symbol DBF4 contributors: mct/npt - updated : 04-01-2012
HGNC name DBF4 homolog (S. cerevisiae)
HGNC id 17364
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 3923 - 674 - Romero (2008)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, interphase, S, checkpoint, G1S
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short N-terminal region that targets CDC7-DBF4 kinase to CDC5
  • putative site for phosphorylation by CDK
  • PEST protease cleavage sites, nuclear localization signals (NLS)
  • a short-looped zinc finger-like domain
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae DBF4 kinase
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • essential for the G1/S transition and initiation of DNA replication to Saccharomyces
  • involved in proliferation, and aggressiveness of prolactin pituitary tumors (Wierinckx 2007)
  • CDC7-DBF4 is a conserved protein kinase required for the initiation of DNA replication
  • CDC7-DBF4 prevents inappropriate exit from mitosis by inhibiting Polo kinase and functions in the spindle position checkpoint
  • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex with CDC7 capable of phosphorylating MCM2 protein
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to CDC7 (regulatory partner of the CDC7 serine/threonine protein kinase, which is essential for the activation of individual ori sites throughout S phase in eukaryotic cells)
  • CDC7/DBF4 heterodimer is a novel interactor of PSIP1 (
  • CDC7-DBF4 interaction with CDC5
  • bipartite interaction between CDC7 and DBF4 subunits facilitates ATP binding and substrate recognition by the CDC7 kinase
  • cell & other
    REGULATION
    Other regulated by by transcription and protein degradation.
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS