protein
| ACTH is the only melanocortin ligand that can activate the ACTH receptor MC2R |
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in the presence of MGRN1 the MC2R is ubiquitinated and, after ACTH stimulation, evidence of multi-monoubiquitination appears |
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MRAP expression enhanced MC2R cell-surface expression as well as concentration-dependent cAMP accumulation |
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MRAP2 transports the MC2R to the cell surface but might prevent activation |
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requires melanocortin receptor accessory protein 1 (MRAP) for formation of active receptor and for its transport to the cell membrane |