SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
|
| intracellular,nucleus,nucleoplasm
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| mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes |
basic FUNCTION
| plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex |
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important cofactor in beta-catenin/TCF gene regulation in normal and neoplastic cells, likely functioning in chromatin remodeling |
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may be able to bind plasminogen at cell surface and enhance plasminogen activation |
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possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity |
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essential for the box C/D snoRNP biogenesis |
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involved in transcription, DNA damage response, snoRNP assembly, cellular transformation, cancer metastasis |
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mitosis specific function in regulating microtubule assembly |
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is required for the histone acetyltransferase activity of the TIP60 complex, critical for dephosphorylation of phospho-H2AX (J |
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remodeling factor that possesses both ATPase and DNA helicase activities |
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essential for the function of both embryonic pluripotent cells and adult hematopoietic stem cells |
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RUVBL1 and RUVBL2, also known as Pontin and Reptin, are AAA+ proteins essential in small nucleolar ribonucloprotein biogenesis, chromatin remodelling, nonsense-mediated messenger RNA decay and telomerase assembly |
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RUVBL1, RUVBL2 act as molecular adaptors that can substitute for one another to facilitate the optimal assembly, heat stability, and function of the TIP60 complex |
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RUVBL1, RUVBL2 are required for efficient transcription of type I interferon-stimulated genes |