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FLASH GENE
Symbol GADD45G contributors: mct - updated : 03-04-2019
HGNC name growth arrest and DNA-damage-inducible, gamma
HGNC id 4097
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1087 - 159 - 2016 26521045
- - 1700 - - liver 2016 26521045
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
nervousbraindiencephalon   
Reproductivefemale systemovary   
 male systemprostate   
 male systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY ribosomal protein L7AE/gadd45 family
CATEGORY signaling growth factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • involved in negative control of cell growth,DNA repair and/or apoptosis
  • activating MEKK4 and the p38/JNK pathway in response to environmental stress
  • specific role for GADD45G in male fertility and testis development
  • regulates the thermogenic capacity of brown adipose tissue
  • GADD45 family proteins play a crucial role in regulating cellular stress responses and apoptosis
  • plays a critical role in metastasis of prostate and breast cancer cells (PMID
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text negative control of cell growth noteworthy the pituitary cell proliferation
    PATHWAY
    metabolism
    signaling
  • potential signaling cascade, involving GADD45G &
  • 8594; MAPK14 &
    8594; GATA4 &
    8594; SRY, regulating male sex determination
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mediating activation of stress responsive MEKK4,MAPKKK (MAP3Kx)
  • GADD45G is a direct transcriptional target of ASCL1
  • PAX5 was found to be an epigenetically inactivated tumour suppressor that inhibits non-small cell lung cancer (NSCLC) proliferation and metastasis, through down-regulating the CTNNB1 pathway and up-regulating GADD45G expression
  • GADD45A and GADD45G, directly interact with CDK11A and thereby inhibit CDK11A activity, and consequentially SPDEF phosphorylation and degradation, ultimately reducing prostate cancer cell migration and invasion
  • GADD45 proteins bind the JNK kinase mitogen-activated protein kinase kinase 7 (MAP2K7) and inhibit its activity, even under normal physiological conditions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    of GADD45G-ZEB2 axis may contribute to cellular senescence evasion and hepatocellular carcinoma (HCC) development
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • is a candidate gene for male infertility and 46,XY sex reversal in humans
  • Marker
  • GADD45G suppression is a poor prognostic factor in patients with hepatocellular carcinoma (HCC)
  • Therapy target
    ANIMAL & CELL MODELS
  • Gadd45g(-/-) XY mice were born as completely sex-reversed XY-females, whereas lack of Gadd45a and/or Gadd45b did not affect primary sex determination or testis development