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FLASH GENE
Symbol EHF contributors: mct/npt - updated : 03-09-2013
HGNC name ets homologous factor
HGNC id 3246
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 splicing 5397 32.3 277 - 2012 23185370
lacking an in-frame segment of the coding region
9 splicing 5466 34.9 300 dendritic cells 2012 23185370
  • ESE-3B
  • is the functionally most important EHF isoform in dendritic cells
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly
     mouth   highly
    Reproductivemale systemprostate    Homo sapiens
    Respiratorylung    
     respiratory tracttrachea  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunedendritic cell Homo sapiens
    cell lineage
    cell lines carcinomas
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal A domain, involved in transactivation
  • a central AT hook domain
  • C terminal ETS DNA binding domain
  • HOMOLOGY
    interspecies ortholog to murine Ehf
    intraspecies homolog to ETS factor
    Homologene
    FAMILY
  • ETS transcription regulator family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a transcriptional repressor
  • involved in epithelial differentiation and carcinogenesis
  • playing a role in the induction of cellular senescence as a downstream molecule of MAPK14
  • regulates TNFRSF10B expression through Ets binding sequences on the TNFRSF10B promoter
  • ELF3 and EHF play an important role in airway inflammation
  • controls prostate epithelial cell differentiation and stem-like potential
  • key role for EHF in the development of a subset of prostate tumors
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , mitochondrial transport
    text transcriptional repressor
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • directly activates the transcription of RUVBL1, an ATPase associated with chromatin-remodelling complexe
  • DCDC2 is a novel ESE3/EHF oncogenic target in prostate cancer
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate cancer, silenced by methylation of an evolutionarily conserved CpG site in its promoter
    Susceptibility to asthma
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    EHF and RUVBL1 might be promising molecular targets for the treatment of colon tumours
    ANIMAL & CELL MODELS