SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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text
| secreted into conditioned medium, as well as retained on the cell membrane (Tang 2009) |
basic FUNCTION
| exhibiting arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity |
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having the potential to modify the sulfation status of extracellular heparan sulfate proteoglycan (HSPG) glycosaminoglycan chains and thereby to regulate interactions with HSPG-binding proteins (Morimoto-Tomita 2005) |
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removes 6-O-sulfate groups on glucosamine from subregions of intact heparin (Uchimura 2006) |
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tool for deciphering the sulfation requirements in the interaction of protein ligands with heparin/HSPGs and expand the range of potential biological activities of this enzyme (Uchimura 2006) |
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extracellular sulfatase acting on internal glucosamine 6-O-sulfate modifications within heparan sulfate proteoglycans and regulating their interactions with various signaling molecules, including Wnt ligands (Tang 2009) |
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essential transcription factor for beta-type globin gene switching, that specifically activates transcription of the adult beta-globin gene promoter (Perrine 2009) |
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recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivatives (Perrine 2009) |
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extracellular sulfatases SULF1 and SULF2 remove specific 6-O-sulfate groups from heparan sulfate, thereby modulating numerous signalling pathways underlying development and homeostasis |
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regulates the activities of a number of signalling pathways that in many tissues are up-regulated during development and disease |
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promotes growth and metastasis of solid tumors |
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SULF1 and SULF2 differentially contribute to the generation of organ-specific sulfation patterns of heparan sulfate |
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overexpressed in idiopathic pulmonary fibrosis (IPF)and may play a role in regulating TGFB1 signaling in type II alveolar epithelial cells (AECs) |
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SULF1, SULF2 plays an important role in the development of the inner ear |
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SULF1, SULF2 and ERBB1 are likely involved in the signalling pathway from chondroitin sulphate proteoglycans (CSPGs)that leads to inhibition of neurite outgrowth and may regulate structural plasticity and regeneration in the nervous system |
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SULF1/SULF2 enzymes regulate cell signalling that impacts the growth and differentiation of many tissues |
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SULF1 and SULF2 play indispensable roles to maintain glomerular integrity and protective roles in diabetic nephropathy, probably by growth factor modulation |
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is a multifaceted protein involved in triglyceride-rich lipoprotein (TRL) homeostasis and angiogenesis |
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in addition to SULF1, SULF2 also plays an important and overlapping role in the motor neurons (MNs) to oligodendrocyte precursor cells (OPCs) fate change by regulating SHH signaling in the ventral spinal cord |