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FLASH GENE

Symbol

DPT

contributors: mct - updated : 02-11-2016

HGNC name	dermatopontin
HGNC id	3011

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001937 4 - 1749 22 201 - 2011 21398523

EXPRESSION

Rna function	mRNA was strongly expressed in human fetal and adult liver, kidney, and spleen
Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Homo sapiens Nervous ganglia sensory ganglia dorsal root       nerve spinal nerve sciatic     Reproductive female system uterus       Skin/Tegument skin         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains

a binding site in DPT for FN1 was identified as the DPT-4 (PHGQVVVAVRS) peptide

HOMOLOGY

Homologene

FAMILY

dermatopontin family.

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm
text	located mainly in the cytoplasm of several cell types in the liver, and also in the extracellular matrix of the skin

basic FUNCTION	may be mediating adhesion by cell surface integrin binding
	promoting cell adhesion and cytoplasmic spreading of dermal fibroblasts and accelerating the assembly of collagen into fibrils
	may be one of the regulators used to remodel the uterine extracellular matrix for pregnancy
	can play various roles in different tissues and might be a molecule related to carcinogenesis and the progression of hepatocellular carcinoma via possible interaction with TGF-beta1 and other potential mechanisms
	promotes fibronectin fibril formation probably by changing the fibronectin conformation
	has an accelerating role in fibroblast cell adhesion to the provisional matrix in the initial stage of wound healing
	first non-integrin protein that can activate Fibronectin (FN) and induce FN fibril formation, and in a context of FN activation, may help a wound to heal by accumulating in the wound either from the surrounding ECM or from the serum
	acidic extracellular matrix (ECM) protein that plays a critical role in both ECM structure and wound healing

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	proteoglycan binding
	binding to decorin
	downstream target of vitamin D receptor
	promotes strong epidermal cell adhesion via alpha3beta1 integrin and syndecan
	interacted with Fibronectin (FN) and fibrin and enhanced the cell adhesion activity of FN
	a binding site in DPT for FN1 was identified as the DPT-4 (PHGQVVVAVRS) peptide, and the major binding site in FN1 for DPT was the 14th type III repeat (III14) domain

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in uterine leiomyoma and keloids tumoral     --low   in hepatocellular carcinoma constitutional germinal mutation       in autosomal dominant (AD) familial Meniere disease (FMD)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Dpt-kockout mice exhibit an Ehlers-Danlos syndrome phenotype