basic FUNCTION
| negative regulator of Hsp70 chaperone activity |
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having apoptosis regulator activity, and involved in apoptosis |
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chaperone-regulating protein, functioning as a negative regulator for APOBEC1-mediated apoB mRNA editing through its ability to suppress the Hsp/Hsc70 chaperone activity |
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breast cancer oncogene that can work in combination to influence the transformed phenotype in human mammary epithelial cells |
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involvement in the propagation of ovarian cancer |
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novel regulator of PI3K/Akt signaling to the actin cytoskeleton |
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inhibits PI(3,4,5)P3 degradation following growth factor stimulation, and in its absence, the enhanced 5-ptase activity reduces Akt activation, leading to reduced Akt-dependent signaling to the actin cytoskeleton |