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FLASH GENE
Symbol BAG4 contributors: mct - updated : 21-06-2012
HGNC name BCL2-associated athanogene 4
HGNC id 940
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 4478 - 457 - 2002 12058034
4 - 4370 - 421 - 2002 12058034
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
C terminal BAG domain binding Hsc70/Hsp70 and Bcl2 (containing three-helix bundles; each helix in this bundle is three to four turns shorter than its counterpart in BAG1, which reduces the length of the domain by one-third.)
HOMOLOGY
Homologene
FAMILY
CATEGORY chaperone/stress
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
basic FUNCTION
  • negative regulator of Hsp70 chaperone activity
  • having apoptosis regulator activity, and involved in apoptosis
  • chaperone-regulating protein, functioning as a negative regulator for APOBEC1-mediated apoB mRNA editing through its ability to suppress the Hsp/Hsc70 chaperone activity
  • breast cancer oncogene that can work in combination to influence the transformed phenotype in human mammary epithelial cells
  • involvement in the propagation of ovarian cancer
  • novel regulator of PI3K/Akt signaling to the actin cytoskeleton
  • inhibits PI(3,4,5)P3 degradation following growth factor stimulation, and in its absence, the enhanced 5-ptase activity reduces Akt activation, leading to reduced Akt-dependent signaling to the actin cytoskeleton
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • BAG4 forms a complex with several 5-ptase family members, including INPPL1, INPP5D, INPP5K
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the ATPase domain of HSP70/HSC chaperones
  • binding to the death domain of TNFRSF1A
  • in the absence of TNF and thereby preventing binding of adapter molecules such as TRADD or TRAF2
  • binds to the death domain of TNFRSF12
  • binds to APOBEC1 via its N-terminal region independent of the BAG domain
  • complexes with and inhibits the catalytic activity of the inositol polyphosphate 5-phosphatase INPP5K
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic cancer compared with normal pancreas, correlating with high Akt activation, even in the absence of cell stimulation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may represent a potential prognostic marker for cute lymphoblastic leukemia
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    provide a basis for the development of molecular therapeutics modulating these survival pathways
    ANIMAL & CELL MODELS