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FLASH GENE
Symbol UBE2V2 contributors: mct - updated : 21-10-2011
HGNC name ubiquitin-conjugating enzyme E2 variant 2
HGNC id 12495
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1535 - 145 - 1998 9705497
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
cell lineage
cell lines some cancer lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an acidic domain
  • a C terminal basic domain, lacking the critical cysteine residue essential for E2 catalytic activity
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • putatively involved in the control of differentiation
  • ubiquitin dependent proteolytic protein
  • UBE2V2 along with its heteromeric partner UBE2N can govern the error-free repair of DNA lesions by catalyzing the formation of lysine 63-linked polyubiquitin chains (K63-polyUb)
  • serves a redundant role in human PCNA polyubiquitination
  • CELLULAR PROCESS cell life, differentiation
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with UBE2N (UBE2N-UBE2V2 is required for DNA damage repair but not nuclear factor kappaB (NF-kappaB) activation)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UBE2V2 physical association with Ub is correlated with its ability to promote Lys63-linked Ub chain assembly (
  • interactions between TRIM32 and UBE2V2, and UBE2V1
  • UBE2N is the only known E2 ubiquitin (Ub)-conjugating enzyme that produces Lys-63-linked Ub chain with its cofactor E2 variant UBE2V1 or UBE2V2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS