SUBCELLULAR LOCALIZATION
| plasma membrane,junction
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,nucleus,nucleoplasm
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text
| postsynaptic density |
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colocalizes with MPDZ in the acrosomal region of epididymal spermatozoa where the kinase selectively binds to a region encompassing PDZ domains 10-11 of MPDZ |
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translocates to excitatory synapses following strong glutamatergic stimuli that induce NMDA-receptor (NMDAR)-dependent long-term potentiation in CA1 hippocampal neurons |
basic FUNCTION
| phosphorylation of numerous synaptic substrates including ion channels, other signaling molecules and scaffolding proteins |
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involved in synaptic plasticity and memory formation in the hippocampus |
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required with Ca2+ and calmodulin for an essential step in initiation of centrosome duplication |
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may function in long-term potentiation and neurotransmitter release |
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may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity |
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plays a critical role in the growth of osteosarcoma |
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regulates CHRM4 efficacy and controls the acetylcholine-dopamine balance in the basal ganglia and also the dynamics of movement |
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its activity is necessary for spine enlargement during long-term potentiation, and it is a critical control point in the determination of spine size |
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CAMK2A-dependent processes control synaptic strength and spine size |
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has a central role in regulating neuronal excitability |
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crucial effector of PKD2 Ca++ that both promotes morphogenesis of the pronephric kidney and stabilizes primary cloacal cilia |
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CAMK2A, CAMK2B act in concert, but with distinct functions, to regulate hippocampal synaptic plasticity and learning |
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central role in the neurotoxicology of Cadmium (Cd), suggesting that manipulation of intracellular Ca(2+) level or CAMK2A activity may be exploited for prevention of Cd-induced neurodegenerative disorders |
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role in maintaining the stability of nicotinic acetylcholine receptors |
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importance of tightly controlled autophosphorylation of CAMK2A for normal neuronal function, suggesting that disruption of this event can impair synaptic plasticity and learning, resulting in neurodevelopmental defects |
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kinase activity of CAMK2A plays a crucial role in the proteasomal degradation of NCOR2 |
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is an important decoder of Ca(2+) signals and mediator of synaptic plasticity |
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could decode compartmental dendritic Ca(2+) transients to support remodeling of local synapses |
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CAMK2A activity is a central mechanism for mitochondrial Ca2+ entry |
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is a modulator of mitochondrial Ca2+ homeostasis and a crucial component of a final pathway in heart disease due to ischemia and neurohumoral toxicity |
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acts as a key regulator of osteoblast differentiation |
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plays a key role in N-methyl-D-aspartate (NMDA) receptor-dependent long-term synaptic plasticity |
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is an important nodal point in both acute and chronic modulation of ion channels in both heart and brain |
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CAMK2A, CAMK2B are essential for various forms of synaptic plasticity |
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dual role of CAMK2A as a component of cell-autonomous clockwork and as a synchronizer integrating circadian behavioral activities |
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elevated CAMK2A content promotes a slow-to-fast type fibre shift in regenerating muscle but is not sufficient to stimulate mitochondrial biogenesis in the absence of an endurance stimulus |
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is a regulator of the barrier function of Tight junctions (TJs) |
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CAMK2A controls likely the initiation of the memory reconsolidation process through regulation of the proteasome |
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in addition to MYLK3 contributes to phosphorylation of regulatory light chain in cardiomyocytes |
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plays a previously unappreciated role in autism spectrum disorder(ASD)-related synaptic and behavioral phenotypes |