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FLASH GENE
Symbol ICK contributors: mct/npt/pgu - updated : 15-05-2013
HGNC name intestinal cell (MAK-like) kinase
HGNC id 21219
RNA
TRANSCRIPTS type messenger
text Variants 1 and 2 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 6127 - 632 - 2000 10699974
15 - 6238 - 632 - 2000 10699974
- - 1806 - 292 - 2000 10699974
  • with an alternative C terminus
  • predominantly in the cytoplasm
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly
    Nervousbrainbasal nucleicorpus callosum highly
     brainhindbraincerebellum moderately
     braindiencephalonhypothalamus moderately
     spinal cord   highly
    Reproductivefemale systemovary  moderately
     male systemtestis  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth   
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveenterocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal catalytic domains, related to mitogen-activated protein kinases (MAPKs) and containing a corresponding TDY motif
  • a dual phosphorylation site found in mitogen-activating protein (MAP) kinases
  • C-terminal noncatalytic domains
  • HOMOLOGY
    interspecies homolog to rattus S/T-protein kinase
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
  • CDK subfamily
  • CATEGORY enzyme , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • nuclear Cdc2-related kinase, prototype for a new group of MAPK-like kinases requiring dual phosphorylation at TDY motifs
  • MAK and ICK require dual phosphorylation in a TDY motif catalyzed by an unidentified human threonine kinase and tyrosine autophosphorylation
  • may play a role in cardiac development
  • playing an important role in intestinal epithelial cell proliferation and differentiation
  • plays a key role in the development of multiple organ systems
  • highly conserved serine/threonine protein kinase, that supports cell proliferation and G(1) cell cycle progression
  • important role for ICK in modulating the activity of MTOR through phosphorylation of Raptor Thr-908, implicating a potential signaling mechanism by which ICK regulates cell proliferation and division
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Mg2+
  • protein
  • Scythe is a physiological substrate for ICK
  • interacts with the MTOR/Raptor complex in cells, and is able to phosphorylate Raptor Thr-908
  • cell & other
    REGULATION
    activated by dual phophorylation of the TDY motif (Y-159 and T-157), such that it autophosphorylates at Y-159
    ASSOCIATED DISORDERS
    corresponding disease(s) ECO
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS