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FLASH GENE
Symbol CD53 contributors: - updated : 14-12-2005
HGNC name CD53 molecule
HGNC id 1686
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   moderately
 spleen   highly
 thymus   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Blood/Hematopoieticneutrophil
Lymphoid/ImmuneB cell
Lymphoid/Immunemacrophage
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic Hydrophobic
STRUCTURE
motifs/domains
  • four transmembrane hydrophobic domains
  • a major extracellular hydrophilic loop containing 2 potential N-glycosylation sites
  • conjugated GlycoP
    mono polymer complex
    HOMOLOGY
    interspecies ortholog to rattus Cd53
    ortholog to murine Cd53
    homolog to drosophila Tsp39D
    Homologene
    FAMILY transmembrane 4 superfamily member, tetraspanin (TM4SF)
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral to plasma membrane
  • basic FUNCTION
  • may be involved in growth regulation in hematopoietic cells
  • contributing to the transduction of CD2-generated signals in T cells and natural killer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • involved in a complex with integrins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS