basic FUNCTION
| cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells |
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beta(2)-integrin that plays an important role in T-cell accumulation and activation in adipose tissue, and contributes to insulin resistance associated with obesity (Wu 2010) |
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differential involvement of ITGAX and ITGAM in adhesion and subsequent cytoskeletal changes in monocytes exposed to different conditions indicates the importance of each integrin in distinct responses during inflammation (Georgakopoulos 2008) |