Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ID3 contributors: mct - updated : 03-06-2019
HGNC name inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
HGNC id 5362
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1288 - 119 - 2003 12952978
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text during early development
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • basic helix-loop-helix (HLH) motif, lacking the DNA binding basic domain
  • conjugated ubiquitinated
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to Drosophila extra-macro-chaete (emc)
    homolog to murine ld-3
    Homologene
    FAMILY helix loop helix family of proteins
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • inhibing transcription factors of the basic helix loop helix family
  • required for neurogenesis and angiogenesis
  • functions by a novel mechanism, independent of cell fate determination, to mediate the decision of neural crest precursors to proliferate or die
  • important signaling molecule in estrogen stimulated vascularization and may serve as a therapeutic target in the prevention and treatment of vasculoproliferative disorders (
  • involved in tumor growth, invasiveness, metastasis, and angiogenesis
  • repressor of BHLH activity
  • ID1 and ID3 negatively regulate the transition from lineage-specified hemogenic cells to committed hematopoietic progenitors during hematopoiesis of both embryonic stem cells and induced pluripotent stem cell
  • has been implicated in a variety of functions, including regulation of cell cycle progression and B-cell differentiation
  • morphologically, ID2/ID3 proteins seem to be involved in the granulopoietic maturation
  • ID2 and ID3 enforce follicular regulatory T (TFR) cell- checkpoints and control the maintenance and homing of Treg cells
  • is involved in regulatory mechanisms in adipose tissue and regulates angiogenesis in many tissues including adipose tissue
  • play likely a potential role in the underlying regulatory mechanisms of metabolic health in human obesity
  • contributes to the acquisition of molecular stem cell-like signature in microvascular endothelial cells
  • ID3 is the BMP2-induced transcriptional regulator, promoting adult neural stem/precursor cells (NSPCs) differentiation into astrocytes upon CNS injury
  • ID3 expression is high in follicular B lineage cells but declines in germinal center (GC) cells
  • during the GC reaction, ID3 levels decline to activate the expression of genes encoding signaling components that mediate B cell receptor- and or cytokine receptor-mediated signaling to promote the differentiation of GC B cells
  • is required for tumor angiogenesis and regulatory T-cell generation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer with other HLH proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FMR1 (RNA target of FMR1)
  • SMURF2 is an E3 ligase that ubiquitinates ID1 and ID3 (SMURF2-mediated ubiquitination and consequent degradation of ID1 or ID3 plays an important role in the regulation of Id expression in senescent cells
  • ANKRD2 and ID3 cooperatively inhibit myoblast differentiation by physical interaction
  • MDC1 interacts with a helix-loop-helix (HLH)-containing protein called inhibitor of DNA-binding 3 (ID3)
  • cell & other
    REGULATION
    repressed by ZBTB18, repressing ID1, ID2, ID3, ID4 genes during corticogenesis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    neuroblastoma, ovarian adenocarcinoma
    tumoral     --over  
    in Burkitt lymphoma
    constitutional     --other  
    aberrant expressions of endometrial ID3 and CTLA4 are associated with unexplained repeated implantation failure and recurrent miscarriage
    tumoral     --over  
    was associated with shorter survival of medulloblastoma patients, especially in Group 4 medulloblastomas
    Susceptibility
  • to carotid intima-media thickness
  • to coronary artery pathology
  • Variant & Polymorphism SNP
  • common SNP in the ID3 gene linked to loss of ID3 function and increased carotid intima-media thickness
  • association of ID3 SNP rs11574 directly with human coronary artery pathology
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    peptide aptamer, Id1/3-PA7, specifically interacting with ID1 and ID3, could represent a nontoxic exogenous agent that can significantly provoke antiproliferative and apoptotic effects in breast cancer cells, which are associated with deregulated expressi
    ANIMAL & CELL MODELS
  • combined Id1 and Id3 deletion leads to dysregulation of the hematopoietic transcriptional network and multiple defects in erythropoietic development in adult mice