SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,cytosolic,vesicle
|
| intracellular,cytoplasm,cytosolic,microsome
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basic FUNCTION
| in sterol-depleted cells, escorting SREBPs protein from the ER to the Golgi |
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regulating the sterol-dependent transcription of cholesterol biosynthetic genes carrying cis-acting sterol response elements (SREs) |
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subject to endoplasmic reticulum retention upon INSIG1 binding |
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key regulator of activation of SREBPs, which stimulate most enzymes in cholesterol and lipid synthesis |
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crucial role of SCAP-mediated control of cholesterol and lipid metabolism necessary for production of a proper myelin membrane by Schwann cells |
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cellular cholesterol homeostasis is maintained by SCAP, an endoplasmic reticulum (ER) protein with eight transmembrane helices |
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polytopic protein of the endoplasmic reticulum (ER) that controls cholesterol homeostasis by transporting sterol regulatory element-binding proteins (SREBPs) from the ER to the Golgi complex |
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PAQR3 has an important physiological function in modulating obesity, energy metabolism, and leptin signaling |
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enhanced SCAP glycosylation by inflammation induces macrophage foam cell formation |
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cellular cholesterol levels are controlled by endoplasmic reticulum (ER) sterol sensing proteins, which include SCAP and INSIG1 |
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unlike the liver, the intestine requires SCAP to sustain tissue integrity by maintaining the high levels of lipid synthesis necessary for proliferation of intestinal crypts |
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SCAP is required for sterol synthesis and crypt growth in intestinal mucosa |
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SCAP is retrieved from the Golgi and moves to the ER after processing of SREBF under sterol-deficient conditions |
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acts as key glucose-responsive protein linking oncogenic signaling and fuel availability to SREBF-dependent lipogenesis |