Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | FSTL3 | contributors: mct - updated : 28-09-2013 |
HGNC name | follistatin-like 3 (secreted glycoprotein) |
HGNC id | 3973 |
|
RNA |
TRANSCRIPTS | type | messenger |
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|
EXPRESSION |
Type | widely |
tissue |
|
cells |
|
cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
physiological period | pregnancy |
Text | placenta, amniocytes, chorionic villosities |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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| |
| |
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conjugated | GlycoP |
HOMOLOGY |
interspecies | homolog to murine Fstl3 |
Homologene |
FAMILY |
CATEGORY | regulatory , secretory , protooncogene |
SUBCELLULAR LOCALIZATION | extracellular |
intracellular,nucleus |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
text | negative feedback loop regulating activin activity |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
| |
| |
| |
| |
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cell & other |
REGULATION |
activated by | at the transcriptional level by TNF and NFKB1 |
induced by | TGFB through the activin of SMADS (MADHs) proteins | |
with Activin A are induced in heart by myocardial stress |
Other | differently regulated in ovarian granulosa-luteal cells by protein kinase C and A |
ASSOCIATED DISORDERS |
corresponding disease(s) | FSTL3 |
Other morbid association(s) |
|
Susceptibility |
Variant & Polymorphism
| |
Candidate gene
Marker
| Therapy target
| reduced FSTL3 activity (FSTL3 antagonists or activin) might simultaneously reduce visceral adiposity, increase beta cell mass, and improve insulin sensitivity |
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ANIMAL & CELL MODELS |