basic FUNCTION
| actin-binding adaptor protein, interacting with and tyrosine phosphorylated by ZAP70, which is a crucial proximal protein tyrosine kinase for TCR signaling |
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is a novel molecular player in integrin biology that is critical for phagocytosis and firm neutrophil adhesion under flow conditions |
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DBNL and cortactin (CTTN) play distinct roles in podosome regulation |
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role in podosome rosette formation and cell invasion downstream of SRC |
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is of fundamental importance for spreading and migration under shear stress conditions, which are critical prerequisites for efficient polymorphonuclear neutrophils (PMN) extravasation during inflammation |
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F-actin-anchored COBL/DBNL complexes seem crucial for neuromorphogenesis processes, particularly for the postnatal arborization of Purkinje cells representing the source for all motor coordination in the cerebellar cortex |
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critical for organ development and immune response and is important for the regulation of the actin cytoskeleton through its interactions with F-actin and various cytoskeletal and cell signaling proteins |
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actin binding protein, negatively regulating myocardial contractility at the single-cell levels |
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multidomain adaptor protein that is critical for organ development and the immune response |
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is required for proper cell growth control |