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FLASH GENE
Symbol NMU contributors: KTN/npt - updated : 02-04-2008
HGNC name neuromedin U
HGNC id 7859
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 817 - 174 - Wu (2007)
  • a 34 aa signal peptide of 3.6 kda
  • a 33 aa mature peptide of 3.9 kda
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
     pharynx   moderately
     stomach   moderately
    Nervousbraindiencephalonhypothalamus  
    Reproductivefemale systemovary  highly
     female systemuteruscervix moderately
    Respiratoryrespiratory tractlarynx  predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    Connective   highly
    cell lineage
    cell lines
    fluid/secretion highly in lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four potential proteolytic processing sites generating putative associated peptides
  • conjugated Other
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to dog NMU (82.4 pc)
    homolog to chimpanzee NMU (99.4 pc)
    homolog to rattus Nmu (72.1 pc)
    homolog to murine Nmu (74.4 pc)
    homolog to chicken NMU (63 pc)
    Homologene
    FAMILY
  • NmU family
  • CATEGORY regulatory , secretory , signaling neurotransmitter
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • central control of feeding and potent uterine contractile effets, involved in feeding behavior as a catabolic signaling molecule
  • stimulating contractions of the ileum and urinary bladder
  • plays a role in feeding behavior and catabolic functions via CRH (corticotrophin-releasing hormone)
  • acting in the central nervous system, rather than directly on bone cells, to regulate bone remodeling
  • acting as a neuropeptide
  • involved in the regulation of smooth muscle contraction
  • involved in energy regulation
  • implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion , reproduction/sex
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/hearing
  • neuropeptide signaling pathway
  • a component
  • amidation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NMU/NMU1R axis constitutes a growth-promoting autocrine loop in myeloid leukemia cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    deficiency results in an isolated increase in bone formation leading to high bone mass
    Susceptibility associated with overweight and obesity
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target for the treatment of lung cancers
    ANIMAL & CELL MODELS