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FLASH GENE
Symbol LAMC3 contributors: mct - updated : 28-03-2012
HGNC name laminin, gamma 3
HGNC id 6494
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
28 - 6107 - 1575 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestivemouth   highly
Nervousnervecranial nerve  predominantly
Reproductivefemale systemoviduct  lowly
 female systemplacenta  highly
Respiratorylung   lowly
Skin/Tegumentskin   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective   lowly
Epithelialbarrier liningretinal pigment epithelium (RPE) lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 19 amino acids signal peptide (1.8 kDa)
  • four laminin A/neurexin/sex hormone-binding (LNS) globular domains separated by multiple EGF-like motifs within the N terminal short arm allowing the self assembly of chains through interactions of the most terminal globular domain (VI), and a long arm composed of heptad repeats typical of an cell alpha helical coiled-coil protein
  • secondary structure three non identical chains A, B1, B2 (alpha, beta, gamma)
    conjugated GlycoP
    mono polymer heteromer , trimer
    isoforms Precursor a 1568 amino acids mature peptide (130.3 kDa)
    HOMOLOGY
    interspecies homolog to rattus Lamc3 (76.09 pc)
    homolog to murine Lamc3 (75.53 pc)
    Homologene
    FAMILY
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • extracellular matrix
  • apical membrane
  • basic FUNCTION
  • involved in development and stabilization of epithelial structures
  • unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains
  • extracellular cell adhesion molecule localizing to basement membranes and essential for early embryonic development
  • role for LAMC3 in extracellular matrix organization of the somatodendritic compartment
  • CELLULAR PROCESS cell life, differentiation
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of cutaneous basement membrane zone
  • heterotrimerizing with Alpha and BÍta subunits, forming laminin 12, laminin 13 and laminin 15
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OCGA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    sporadic autistic disorder
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS