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FLASH GENE
Symbol SYCP2 contributors: mct/npt - updated : 09-03-2007
HGNC name synaptonemal complex protein 2
HGNC id 11490
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
44 - 5497 175.5 1530 - Schalk (1999)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Endocrineneuroendocrinepituitary  highly
Reproductivefemale systembreastmammary gland highly
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 14S/T-P and 36S/T-S/T motifs putatively involved in DNA binding
  • two potential p34cdc2 (CDC2) target sites
  • two nuclear localization signals (NLS)
  • a C terminal potential coiled-coil structure
  • HOMOLOGY
    interspecies homolog to murine Scp2
    Homologene
    FAMILY
  • SYCP2 family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the structural organization of meiotic prophase chromosomes
  • required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division
  • acts as a linker between SYCP1 and SYCP3 and therefore would be the missing connecting link between lateral elements and transverse filaments essential for proper chromosome synapsis (Winkel 2009)
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of synaptonemal complex protein 2, axial element
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • SYCP2 interacting with SCYP3 (associate with the centromere regions of male, but not female, metaphase-I chromosomes, suggesting a sex-specific function for the two proteins)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS