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FLASH GENE
Symbol CDK14 contributors: mct - updated : 21-08-2013
HGNC name cyclin-dependent kinase 14
HGNC id 8883
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 4953 - 451 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas   highly
Hearing/Equilibriumearinnercochlea highly
Lymphoid/Immunelymph node   highly
Nervousbrain   highly
Reproductivefemale systemovary  highly
 male systemtestis  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousglia
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • tyrosine kinase, catalytic domain
  • HOMOLOGY
    interspecies homolog to murine pftk1
    intraspecies homolog to cdc2 kinase
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • CDC2/CDKX subfamily
  • CATEGORY enzyme , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • acting as a cyclin-dependent kinases that regulates cell cycle progression and cell proliferation
  • confers hepatocellular carcinoma cell motility through inactivating the actin-binding motile suppressing function of TAGLN2 via phosphorylation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • formed a ternary complex with the cell cycle inhibitor CDKN1A in cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically interacted with cyclin D3 (CCND3)
  • CCNY, was identified as a CDK14 interacting protein
  • biological cascade that involved the phosphorylation activation of CALD1 by CDK14 in promoting formation of actin stress fibers
  • unphosphorylated TAGLN2 in CDK14-suppressed cells elicited strong actin-binding ability, a mechanism that possibly halts the actin cytoskeleton dynamics
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS