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FLASH GENE
Symbol CCL27 contributors: mct/npt - updated : 13-01-2010
HGNC name chemokine (C-C motif) ligand 27
HGNC id 10626
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 469 12.6 112 - Ishikawa-Mochizuki, Morales (1999)
- - 800 - - brain,thymus,placenta lowly Ishikawa-Mochizuki (1999)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
Endocrineneuroendocrinepituitary   
Reproductivemale systemtestis   
Respiratorylung    
Skin/Tegumentskin   predominantly
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES basic ,globular
STRUCTURE
motifs/domains
  • twenty four AA signal peptide
  • HOMOLOGY
    interspecies ortholog to murine Scya27
    homolog to Drosophila eg:bacr25b3.3
    homolog to C.elegans K04C2.5
    Homologene
    FAMILY
  • intercrine beta family (CC chemokine)
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • mediating homing of lymphocytes to cutaneous sites, and playing a role in T cell-mediated skin inflammation
  • selectively attracts a tissue-specific subpopulation of memory lymphocytes (Morales 1999)
  • plays a critical role in the organization of skin-associated immune responses by regulating T cell homing under homeostatic and inflammatory conditions (Pivarcsi 2007)
  • promotes migration of cutaneous lymphocyte-associated antigen-positive lymphocytes into the skin (Campanati 2007)
  • CELLULAR PROCESS cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    text immunoregulatory and inflammatory processes
    PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to receptor CCR10/GPR2 for skin homeostasis and the initiation of skin inflammation
  • interacts with SELPLG
  • ligand of CCR10
  • cell & other
    REGULATION
    activated by activated and upregulated by IL1B,TNF
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in skin lesions of atopic dermatitis, contact dermatitis and psoriasis
    tumoral       gain of function
    led to decreased leukocyte recruitment to cutaneous tumor sites and significantly enhanced primary tumor growth (Pivarcsi 2007)
    constitutional     --low  
    in cutaneous expression during administration of etanercept in psoriasis could be considered a favourable prognostic marker (Campanati 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS