Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PMVK contributors: mlc - updated : 24-10-2007
HGNC name phosphomevalonate kinase
HGNC id 9141
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1307 - 192 - Ewing (2007)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Endocrinepancreas   highly
Lymphoid/Immunelymph node   highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal peroxisomal targeting sequence (PTS2)
  • a C terminal PTS1 sequence
  • mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • phosphomevalonate kinase ATP dependent
  • converting melanovate 5-P into M5-PP in the pathway for the synthesis of cholesterol and isoprenoids (minor role of peroxisomes in isoprenoid biosynthesis)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component a structural constituent of membranes and precursor for bile acids and steroid hormones
    INTERACTION
    DNA
    RNA
    small molecule other,
    protein
    cell & other
    REGULATION
    induced by sterol
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS