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FLASH GENE
Symbol PMPCB contributors: mct - updated : 16-05-2018
HGNC name peptidase (mitochondrial processing) beta
HGNC id 9119
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3939 - 489 - 2009 19580345
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveintestinelarge intestinecolon moderately
 liver   moderately
 stomach   highly
Lymphoid/Immunelymph node   moderately
 thymus   predominantly
Reproductivefemale systemuterus  moderately
 female systemplacenta  moderately
 male systemprostate  moderately
 male systemtestis  moderately
Respiratorylung   moderately
Urinarykidney   highly
Visualeye   moderately
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period
cell cycle     cell cycle, M
Text M phase phosphoprotein
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
zinc binding region
conjugated PhosphoP
mono polymer heteromer , dimer
HOMOLOGY
Homologene
FAMILY
  • insulinase family
  • peptidase M16 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • acting as a mitochondrial processing peptidase
  • catalytic subunit cleaving presequences from mitochondrial protein precursors
  • catalytic subunit of the essential mitochondrial processing protease (MPP), which is required for maturation of the majority of mitochondrial precursor proteins
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    text involved in transit peptide
    PATHWAY
    metabolism
    signaling
    a component heterodimer of alpha and beta subunits
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+ (per subunit)
  • protein
  • mitochondrial processing peptidase PMPCB generates an intermediate form of AFG3L2 that is matured autocatalytically
  • new role for PMPCB in PINK1 import and mitochondrial quality control via the PINK1–Parkin pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MMDS6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS