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FLASH GENE
Symbol PRKRIR contributors: mct - updated : 30-08-2012
HGNC name protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
HGNC id 9440
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 3202 52 761 - 2011 21910972
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinesmall intestine  highly
Reproductivefemale systemovary  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a THAP domain, a zinc-dependent sequence-specific DNA-binding domain belonging to the zinc-finger superfamily
  • C-terminal domain required for physical interaction and the signal augmentation
  • HOMOLOGY
    intraspecies homolog to HSP (90kDa)
    Homologene
    FAMILY PRK family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • protein kinase,double stranded RNA dependent inhibitor,particularly of P58
  • may function as zinc-dependent sequence-specific DNA-binding factors with roles in proliferation, apoptosis, cell cycle, chromosome segregation, chromatin modification, and transcriptional
  • synergistically enhances type I IFN production mediated by a signal activated- or constitutively active form of regulation of DDX58
  • novel positive regulator controlling the DDX58-IFN production system through protein stability control
  • inhibits ubiquitination of DDX58 and suppresses proteasomal degradation of DDX58 proteins, thereby enhancing DDX58-mediated signaling pathways for IFNB synthesis
  • novel positive regulator of DDX58-mediated antiviral signaling pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DDX58 interacting protein (DDX58 interacts through the C-terminal domain of PRKRIR, and the N-terminal region of PRKRIR potentially possesses inhibitory functions to block DDX58 interaction)
  • selectively acts on the DDX58-mediated IRF3 activation and type I IFN synthesis, but not IFIH1
  • cell & other
    REGULATION
    induced by interferon-inducible
    in the virus-infected cells through NLRC5 activation, and controlling the activity of the antiviral protein PKR
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS