basic FUNCTION
| characterized by its ability to bind the two chaperones, HSP70 and HSP90 |
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provides a physical link between HSP70 and HSP90 and modulates the activities of both of these chaperone proteins |
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displays broad anti-aggregation functions and has a critical function in preventing protein misfolding pathologies |
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functional role, in preventing the co-aggregation of HSP70 with SNCA, thereby reducing the toxicity of amyloidogenesis |
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substrate of GRK5 in cells, and phosphorylation of ST13 by GRK5 plays a role in modulating CXCR4 internalization |