basic FUNCTION
| plays a role in regulating cell motility |
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intracellular phosphatase that negatively regulates the Akt/PKB signaling cascade, and is similar to its relative PTEN in this respect |
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inhibit cell growth, enhance serum withdrawal-induced apoptosis, and specifically downregulate the PI3K/Akt signalling pathway |
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thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility |
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large intracellular proteins believed to link the extracellular matrix to the cytoskeleton via integrins |
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negatively regulates the Akt signalling pathway and enhances apoptosis in addition to inhibiting cell migration |
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focal adhesion-localized tensin 2 which negatively regulates DLC1 to permit Rho-mediated actomyosin contraction and remodeling of collagen fibers |
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in addition to regulating cytoskeletal dynamics, influences phosphoinositide-Akt signalling through its PTPase domain |
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have the potential to be phosphatases as only their PTPase domains house a cysteine residue that is essential for catalytic activity |
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may have the unique ability amongst its family members to regulate both cytoskeletal dynamics and survival signalling pathways in parallel |
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important new mediator in THPO/MPL pathway and has a positive affect on cellular growth, at least in part through its effect on the PI3K/Akt signaling |
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distinct differences in the cellular expression of TNS1, TENC1, and TNS3, suggesting that they may be able to function independently of each other in the kidney and the small intestine |
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is an intracellular actin-binding protein that bridges the intracellular portion of transmembrane receptors to the cytoskeleton, thereby regulating signalling for cell shape and motility |
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role of TNS2 as a relevant PTPase contributing to skeletal muscle atrophy |