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FLASH GENE
Symbol TNS2 contributors: mct - updated : 22-01-2018
HGNC name tensin 2
HGNC id 19737
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
29 - 4690 - 1285 - 2002 11792844
29 splicing 4952 - 1419 - 2002 12470648
29 splicing 4862 - 1409 - 2002 12470648
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiens
Digestiveintestinesmall intestine    Mus musculus
 liver   highly Homo sapiens
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveenterocyte Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • actin-binding domain
  • the Src homology 2 (SH2) domain
  • the phosphotyrosine binding (PTB) domain , that predominantly interacts with a novel site on DLC1, not the canonical NPXY motif
  • C1 domain localised preferentially to the nucleus
  • a phosphatase (PTPase) domain that revealed an active site-like pocket receptive towards phosphoinositides
  • HOMOLOGY
    Homologene
    FAMILY
  • tensin family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • plays a role in regulating cell motility
  • intracellular phosphatase that negatively regulates the Akt/PKB signaling cascade, and is similar to its relative PTEN in this respect
  • inhibit cell growth, enhance serum withdrawal-induced apoptosis, and specifically downregulate the PI3K/Akt signalling pathway
  • thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility
  • large intracellular proteins believed to link the extracellular matrix to the cytoskeleton via integrins
  • negatively regulates the Akt signalling pathway and enhances apoptosis in addition to inhibiting cell migration
  • focal adhesion-localized tensin 2 which negatively regulates DLC1 to permit Rho-mediated actomyosin contraction and remodeling of collagen fibers
  • in addition to regulating cytoskeletal dynamics, influences phosphoinositide-Akt signalling through its PTPase domain
  • have the potential to be phosphatases as only their PTPase domains house a cysteine residue that is essential for catalytic activity
  • may have the unique ability amongst its family members to regulate both cytoskeletal dynamics and survival signalling pathways in parallel
  • important new mediator in THPO/MPL pathway and has a positive affect on cellular growth, at least in part through its effect on the PI3K/Akt signaling
  • distinct differences in the cellular expression of TNS1, TENC1, and TNS3, suggesting that they may be able to function independently of each other in the kidney and the small intestine
  • is an intracellular actin-binding protein that bridges the intracellular portion of transmembrane receptors to the cytoskeleton, thereby regulating signalling for cell shape and motility
  • role of TNS2 as a relevant PTPase contributing to skeletal muscle atrophy
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with DLC1 in a PTB domain-dependent manner
  • interaction between DISC1 and TNS2
  • TNS2 is a novel protein tyrosine phosphatase (PTPase) of IRS1 that acts as a mediator to reduce IRS1 under a catabolic condition, resulting in muscle atrophy
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    anti-metastatic therapies may benefit from restoring or preserving tensin expression in primary tumors
    ANIMAL & CELL MODELS