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FLASH GENE
Symbol NLGN1 contributors: mct/pgu - updated : 11-12-2009
HGNC name neuroligin 1
HGNC id 14291
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 4918 - 823 - 2009 19730411
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain   highly
Reproductivefemale systemovary  lowly
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain lowly
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal specific interaction with the GOPC PDZ domain
  • extracellular domain sufficient to induce assembly of functional presynaptic terminals, while the intracellular domain was required for terminal maturation
  • HOMOLOGY
    interspecies homolog to rattus neuroligin 1
    Homologene
    FAMILY
  • neuroligin (Nlgn) family of postsynaptic transmembrane proteins
  • type-B carboxylesterase/lipase family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text post synaptic
    basic FUNCTION
  • mediating cell to cell interactions between neurons
  • triggering presynaptic development in contacting axon
  • induces apparent synapse formation by binding to presynaptic alpha-neurexins
  • essential role for presynaptic terminal maturation
  • also involved in critically controls key steps of presynaptic bouton maturation
  • performs diverse synaptic functions by mechanisms that include as essential components of alpha-neurexin binding and neuroligin dimerization, but extend beyond these activities
  • with CDH2, cooperate to control vesicle clustering at nascent synapses
  • postsynaptic adhesion protein that control the maturation and function of synapses in the central nervous system (CNS)
  • NLGN1 and NLGN2 are essential for excitatory and inhibitory synaptic functions
  • postsynaptic cell-adhesion protein specific for excitatory synapses, which shares a high degree of similarity with acetylcholinesterase
  • acts as a nucleating factor during the APP aggregation process, stimulating the formation of APP oligomers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text formation and remodeling of central nervous system synapses
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • beta neurexins
  • interacting with GOPC (GOPC interacts with many other proteins, such as the Wnt receptors Frizzled 8 and neuroligin via its PDZ domain)
  • cooperation of CDH2 and NLGN1 via the postsynaptic scaffolding web is required to transsynaptically induce presynaptic vesicle clustering
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS