basic FUNCTION
| mediating cell to cell interactions between neurons |
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triggering presynaptic development in contacting axon |
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induces apparent synapse formation by binding to presynaptic alpha-neurexins |
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essential role for presynaptic terminal maturation |
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also involved in critically controls key steps of presynaptic bouton maturation |
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performs diverse synaptic functions by mechanisms that include as essential components of alpha-neurexin binding and neuroligin dimerization, but extend beyond these activities |
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with CDH2, cooperate to control vesicle clustering at nascent synapses |
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postsynaptic adhesion protein that control the maturation and function of synapses in the central nervous system (CNS) |
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NLGN1 and NLGN2 are essential for excitatory and inhibitory synaptic functions |
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postsynaptic cell-adhesion protein specific for excitatory synapses, which shares a high degree of similarity with acetylcholinesterase |
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acts as a nucleating factor during the APP aggregation process, stimulating the formation of APP oligomers |
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cell adhesion molecule, that is critical for the formation and consolidation of synaptic connectivity and is involved in vascular development |
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NLGN1 and NLGN2 having a role in memory consolidation and strengthening |
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postsynaptic adhesion molecule involved in the regulation of glutamatergic transmission |
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differences in the properties of the synaptogenic activities of NLGN1 and LRRTM2, although both transsynaptically interact with presynaptic neurexins |