Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DOCK9 contributors: mct - updated : 09-03-2011
HGNC name dedicator of cytokinesis 9
HGNC id 14132
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
61 - 7544 - 2069 - 2008 18499258
57 - 7661 - 2068 - 2008 18499258
- - 3994 - 1254 - 2008 18499258
- - 4111 - 1253 - 2008 18499258
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestine   lowly
 liver   lowly
Nervousbrainlimbic systemhippocampus moderately Homo sapiens
 brainforebraincerebral cortex   Homo sapiens
Respiratorylung   moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text
  • placenta, highly
  • strongly expressed in the developing brain
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal CZH1 domain, conserved among CZH proteins, and the Pleckstrin homology domain are involved in membrane localization, CDC42 activation, and regulation of dendrite growth
  • a DHR-2 (CZH-2) domain
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to rattus TRG protein
    intraspecies paralog to DOCK11 (52p100))
    Homologene
    FAMILY
  • superfamily of guanine nucleotide exchange factors for Rho GTPases
  • Dock180-related family of proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • CDC42 guanine nucleotide exchange factor, having potential guanyl-nucleotide release factor activity
  • implicated in cell migration, phagocytosis of apoptotic cells, T-cell activation and neurite outgrowth, and probably arose relatively early in eukaryotic evolution
  • specific guanine-nucleotide exchange factor (GEF) for CDC42
  • plays an important role in dendrite growth in hippocampal neurons through activation of CDC42
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component dimerizes via the CDC42-binding CZH2 domain
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with CDC42 via the CZH2 doamin
  • interacting with Rac2 and Cdc42 (specifically recognize Rac2 and Cdc42 through its switch 1 as well as 2-3 regions)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    promoted dendrite growth
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS