SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,cytosolic,microsome
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,nucleus
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text
| in the nucleus during interphase |
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during mitosis, localizes to the cytoplasm, in the centrosome |
basic FUNCTION
| poly ADP-ribose glycohydrolase, responsible for rapid turnover for ADP-ribose polymer |
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may play an important role in regulating cell cycle progression and centrosome duplication |
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specific involvement of PARG in the cellular response to oxidative DNA damage |
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is a novel and critical component of SSBR (single-strand break repair) that accelerates this process in concert with PARP1 |
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catabolic enzyme that cleaves ADP-ribose polymers synthesized by members of the poly (ADP-ribose) polymerase (PARP) family of enzymes |
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PARP or PARG is associated with the neuronal death in a variety of neurodegenerative diseases |
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PARP1 and PARG regulates various cellular processes in response to genotoxic stress ( |
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only protein capable of specific hydrolysis of the ribose-ribose bonds present in PAR (Poly(ADP-ribose) chains, and its deficiency leads to cell death |
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probably has influence on ATM/TP53 pathway and metabolic activation of Benzo(a)pyrene |
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removes poly(ADP-ribose) subunits from proteins that have previously been modified by poly(ADP-ribose) polymerase |