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FLASH GENE
Symbol CCL26 contributors: mct - updated : 05-12-2008
HGNC name chemokine (C-C motif) ligand 26
HGNC id 10625
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1800 - - . highly in heart and liver . lowly in skeletal muscle and kidney Guo
4 - 562 - 94 . lowly in heart, liver, skeletal muscle and kidney Guo, Lee (2008)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveintestinesmall intestine   
 liver   predominantly
Reproductivefemale systemovary  lowly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
a 23 amino acid signal peptide
secondary structure an unstructured N terminus before the first two conserved Cys, an irregularly structured N-loop following the second conserved cys, a single turn of 3(10)-helix, a three stranded antiparallel beta-sheet, an alpha-helix and an unstructured C terminal tail
mono polymer monomer
HOMOLOGY
interspecies homolog to C.elegans y116f11b.1
homolog to Drosophila eg:bacr25b3.3
Homologene
FAMILY intercrine beta family
CATEGORY immunity/defense , signaling cytokine
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • lymphocyte chemoattractant (chemotractive for eosinophils and basophils)
  • acting as a CCR3 ligand
  • inhibiting CCL2 -mediated responses, thus acting as a natural antagonist for CCR2 and exerting a repulsive effect on monocytes
  • first chemokine that features broadband antagonistic activities, suggesting that it may have a modulatory rather than an inflammatory function
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS inflammation
    text anti-pathogen response
    PATHWAY
    metabolism
    signaling signal transduction
    cell to cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to receptor CCR3
  • antagonizing CCR1, CCR2, CCR5
  • CREB1 gene silencing decreased IL13-induced transcription of eotaxin-3 (CCL26)
  • cell & other
    REGULATION
    induced by IL13 and IL14 in HUVECand IL4
    Other regulated by STAT6 (in dermal fibroblasts)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to asthma and total IgE dosage
    Variant & Polymorphism SNP 77C > T, +716A > G, EOT 3 +1579G > A increasing the risk of asthma
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    allergy  
    CCR3 and CCR5 receptor/ligand signaling pathways may be important targets for development of novel mechanism-based adjunctive therapies designed to abrogate the chronic inflammation associated with airway diseases
    ANIMAL & CELL MODELS