SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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text
| apical vesicles of thick ascending limb of Henle loop |
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localization at the mitotic spindle poles and colocalization with other ciliary proteins such as nephrocystin-1 and kinesin family member 3A |
basic FUNCTION
| may be playing a role in regulating the circulating activity of cytokines |
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may be helping to maintaining the integrity of the loop of Henle |
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glycosylphosphatidylinositol (GPI)-linked membrane protein, released into the urine after the loss of its hydrophobic anchor, probably by the action of a phospholipase or protease |
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important role in antibacterial host defense but also in inflammatory disorders of the urogenital tract |
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potently activate macrophages and dendritic cells (DC) via the toll-like receptor 4 (TLR4) pathway |
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having a possible role in renal development |
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major genetic susceptibility locus for chronic kidney disease (CKD), further emphasizing the importance of UMOD in renal physiology |
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participates in renal sodium transport via KCNJ1 channel regulation |