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FLASH GENE
Symbol LRRFIP1 contributors: mct - updated : 20-06-2012
HGNC name leucine rich repeat (in FLII) interacting protein 1
HGNC id 6702
RNA
TRANSCRIPTS type messenger
text specific alternatively spliced transcripts 3.9 and 2.8kb expressed in heart and skeletal muscle (Fong)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
24 - 4109 - 640 - 1999 10366446
12 - 3599 - 394 - 1999 10366446
11 - 4510 - 808 - 1999 10366446
10 - 4438 86.4 784 - 1999 10366446
8 - 4342 - 752 - 1999 10366446
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   highly
Cardiovascularheart   highly
Digestiveliver   highly
Endocrinepancreas   highly
Nervousbrain   moderately
Reproductivemale systemtestis  moderately
Respiratorylung   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Blood/Hematopoieticplatelet Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text heart highly
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
coiled motifs that interact with the LRR domain of FLI
HOMOLOGY
interspecies homolog to murine Lrrfip1
homolog to Drosophila CG8507
intraspecies homolog to TAR RNA interacting protein
Homologene
FAMILY
CATEGORY regulatory , RNA associated , protooncogene
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton
intracellular,nucleus
basic FUNCTION
  • providing a link between RNA and the actin cytoskeleton
  • transcriptional repressor overexpressed in cancer cell lines with a role in regulating expression of the EGFR
  • being the first TNF-alpha repressor identified
  • recruited to RNA-containing vesicles and potentilly participates in cell responses to virus at early time points, being important for type I IFN induction
  • functions as a component of the platelet cytoskeleton, where it interacts with the actin-remodeling proteins Flightless-1 and Drebrin
  • regulator of toll-like receptor (TLR) pathway signaling
  • potentially phosphorylated in response to immunologic stimuli and it is directed to lysosomal structures
  • plays potentially an important role in colorectal cancer metastasis by regulating RHOA-induced cell adhesion, migration, and invasion
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription repressor
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to double-stranded GC-rich RNA
    small molecule
    protein
  • binding to FLI (leucine-rich repeat)
  • interacted directly with CTNNB1, GRIP1 and EP300 and enhanced their activity
  • MYD88 interacting with LRRFIP2 and LRRFIP1, and both are positive regulators of NF-kappaB activity
  • interacted with beta-catenin and promoted the activation of beta-catenin, which increased IFN-beta expression by binding to the C-terminal domain of the transcription factor IRF3
  • cell & other
    REGULATION
    induced by phorbol esters
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to abdominal adiposity
    Variant & Polymorphism SNP rs11680012 was associated with abdominal adiposity (
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS