Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NME2 contributors: mct/ - updated : 27-12-2023
HGNC name non-metastatic cells 2, protein (NM23B) expressed in
HGNC id 7850
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 822 17.16 152 - 2022 35259022
5 - 810 17.16 152 - 2022 35259022
4 - 763 17.16 152 - 2022 35259022
5 - 702 17.16 152 - 2022 35259022
4 - 577 - 82 - 2022 35259022
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
 pharynx   highly
 salivary gland   highly
Skin/Tegumentskin   highly
Visualeye   highly
cell lineage
cell lines erythroleukemia lines
fluid/secretion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative leucine-zipper domain
  • a Kpn (Drosophila Killer of prune) loop
  • a RGD domain
  • a C terminal extension preceded by the YEEEEP motifs
  • HOMOLOGY
    Homologene
    FAMILY
  • nm23 nucleoside diphosphate kinase gene (NDK) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • involved in the phosphorylation of nucleoside diphosphates
  • acting as a transcription regulator for myc
  • interacting with membrane receptor and constituting a novel molecular regulatory mechanism of GPCR endocytosis
  • NME2 associates with telomerase and reduces telomerase activity, and sustained NME2 expression resulted in reduced telomere length in aggressive human cancer cells
  • novel role for NME2 as a telomere binding protein that can alter telomerase function and telomere length
  • NME1, NME2 have likely differential abilities to modulate tumorigenesis
  • NME1 and NME2 have been identified as potential canonical transcription factors that regulate gene transcription through their DNA-binding activities
  • NME1, NME2 catalyze the transfer of gamma-phosphate from nucleoside triphosphates to nucleoside diphosphates by a ping-pong mechanism involving the formation of a high-energy phosphohistidine intermediate
  • NME2, can additionally act as a protein histidine kinase
  • addition of NME1 or NME2 to DNM2 facilitates DNM2 oligomerization and increases GTPase activity, both required for vesicle scission
  • critical role of NME2 in endothelial damage via the modulation of the hexosamine biosynthesis pathway (HBP)
  • NME1, but not NME2, acts specifically to inhibit EMT and prevent the earliest stages of metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    pyrimidine biosynthetic pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ITGB1BP1
  • regulating the expression of MYC, PDGFA, and gelatinase A
  • complexing with Gbetagamma dimers contributing to G protein activation
  • interaction of HERC5 with the metastasis suppressor NME2 (Hochrainer 2008)
  • MDM2 expression causes the loss of NME2 cell motility regulatory function
  • PIWIL2 induces MYC expression by interacting with NME2 and regulates MYC-mediated tumor cell proliferation
  • NME2 interacts with PTPRS, and NME2 associates with PTPRS to elicit neurite outgrowth inhibition in response to chondroitin sulfate proteoglycans (CSPGs)
  • PGAM5 functions as a phosphohistidine phosphatase that specifically associates with and dephosphorylates the catalytic histidine on NME2
  • by dephosphorylating NME2, PGAM5 negatively regulates CD4(+) T cells by inhibiting NME2-mediated histidine phosphorylation and activation of the KCNN4
  • important role for cytoplasmic IRF6 in regulating the availability or localization of the NME1/2 complex and thus the dynamic behavior of epithelia during lip/palate development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in neuroblastoma, lung tumors, thyroid carcinoma with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene for malignant pleural mesothelioma
    Marker
    Therapy target
    ANIMAL & CELL MODELS