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FLASH GENE
Symbol MARCO contributors: - updated : 12-02-2004
HGNC name macrophage receptor with collagenous structure
HGNC id 6895
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Digestiveliver    
Lymphoid/Immunelymph node    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
Text in other tissues following systemic,bacterial infection
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short N terminal cytoplasmic domain with 2 potential glycosylation sites.
  • a transmembrane domain followed by an extracellular part with a spacer domain III
  • a triple helical collagenous domain
  • a C terminal scavenger receptor cysteine-rich domain
  • HOMOLOGY
    interspecies homolog to murine Marco
    Homologene
    FAMILY
    CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION playing a role in innate immune response
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
    binding Gram-positive and Gram- negative bacteria
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS